1. Department of Psychology, School of Health, Shandong University of Traditional Chinese Medicine, Jinan 250000, China; 2. Faculty of Education, Northeast Normal University, Changchun 130024, China; 3. School of Humanities and Social Sciences, Binzhou Medical University, Yantai 264003, China; 4. Department of Psychology, Tongji University, Shanghai 200092, China; 5. Centre for Brain, Mind and Education, Shaoxing University, Shaoxing 312000, China
Abstract：Misophonia is a specific emotional psychological disorder that leads to negative emotions, physiological arousal and abnormal behaviors in response to certain everyday sounds, and seriously affects the physical and psychological development and social adjustment of patients. Misophonia overlaps with psychosomatic disorders such as obsessive-compulsive disorder in symptoms, but it shows unique neurological characteristics in insula, orbitofrontal cortex and motor cortex. Further brain imaging revealed abnormal functional connections between the audiovisual cortex, limbic system, autonomic nervous system, insula and motor cortex in misophonia. The intense world theory and hyper-mirroring model provide the clinical psychological and neural mechanism explanation for misophonia in the abnormal aspects of attentional system, perceptual system, emotional system and perception-action connection system. On this basis, new ideas were provided for perfecting and constructing the treatment of misophonia from the perspectives of revising cognition, remodeling neural activity and improving functional connectivity of brain regions by distinguishing the unimodal intervention and multimodal intervention.
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