Abstract：Hyperscanning as a technique for measuring brain activity simultaneously from two or more people has been widely used in the research about social interactions. It based on different brain recording devices, for example, functional magnetic resonance imaging (fMRI), electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS) and so on, can monitor between-brains connectivities during dynamic interactions and provide insight into activation patterns not detectable using typical single-person experiments, improving the reality and naturality. This paper reviews the published literature on the hyperscanning and makes summaries on several fields, included (1) trust and fairness: brain regions associated with trust and fairness are located in the cingulate gyrus and temporo-parietal junction; (2) cooperation and competition: the coherence between signals generated by participants’ frontal cortices increases only for cooperation but not during competition, and the gender of partner has some effect on neural synchronization; (3) imitation and action coordination: the alpha –mu band in the right centro-parietal region is a significant neuromarker of social coordination, the increased interpersonal brain synchronization appears in the premotor cortex and centro-parietal cortex that associated with mirror-neuron system; (4) expression, gesture and verbal communication: a larger coherence increases between senders and perceivers, inter-brain coherence in the right hemisphere is caused by non-verbal coordination, whereas synchronization in the left hemisphere results from verbal dialog. In addition to these, a discussion of the possible future uses of hyperscanning to explore patients with psychopathy, including depression, autism and schizophrenia, whose social interactions are impaired also be presented in our paper. Finally, considering of the complexities of hyperscanning, this paper gives some suggestions to improve its applicability.